Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy

BACKGROUND: Diabetic nephropathy (DN), one of the major complications of diabetes, is characterized by albuminuria, glomerulosclerosis, and progressive loss of renal function. Loss of TIMP3, an Extracellular Matrix bound protein affecting both inflammation and fibrosis, is a hallmark of DN in human...

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Publicat a:Clin Transl Med
Autors principals: Casagrande, Viviana, Iuliani, Giulia, Menini, Stefano, Pugliese, Giuseppe, Federici, Massimo, Menghini, Rossella
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
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Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862169/
https://ncbi.nlm.nih.gov/pubmed/33634991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ctm2.305
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