Identification of novel functional Organic Anion-transporting Polypeptide 1B3 (OATP1B3) polymorphisms and assessment of substrate specificity

OBJECTIVE: The uptake carrier Organic Anion-transporting Polypeptide 1B3 (OATP1B3, gene SLCO1B3) is involved in the hepatic clearance of xenobiotics including statins, taxanes and mycophenolic acid. We thought to assess the SLCO1B3 coding region for yet unidentified polymorphisms, and to analyze the...

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Autors principals: Schwarz, Ute I., Meyer zu Schwabedissen, Henriette E., Tirona, Rommel G., Suzuki, Atsuko, Leake, Brenda F., Mokrab, Younes, Mizuguchi, Kenji, Ho, Richard H., Kim, Richard B.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044558/
https://ncbi.nlm.nih.gov/pubmed/21278621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328342f5b1
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