Organic anion transporting polypeptides OATP1B1 and OATP1B3 and their genetic variants influence the pharmacokinetics and pharmacodynamics of raloxifene

<p>Abstract</p> <p>Background</p> <p>Raloxifene, a selective estrogen receptor modulator, exhibits quite large and unexplained interindividual variability in pharmacokinetics and pharmacodynamics. The aim of this study was to determine the role of organic-anion transpor...

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Detalhes bibliográficos
Main Authors: Trdan Lušin Tina, Stieger Bruno, Marc Janja, Mrhar Aleš, Trontelj Jurij, Zavratnik Andrej, Ostanek Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-04-01
Colecção:Journal of Translational Medicine
Assuntos:
Raloxifene
Raloxifene diglucuronide
SLCO1B1
SLCO1B3
Osteoporosis
LC/MS/MS
Acesso em linha:http://www.translational-medicine.com/content/10/1/76
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