Effects of UGT1A1*28 polymorphism on raloxifene pharmacokinetics and pharmacodynamics

AIMS: Raloxifene concentrations were reported to correlate approximately with serum bilirubin levels. Bilirubin is a typical UGT1A1 substrate. Based on these facts, we postulated a hypothesis that UGT1A1 is the key enzyme for metabolic clearance of raloxifene and that the common UGT1A1*28 polymorphi...

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Bibliografiska uppgifter
Huvudupphovsmän: Trontelj, Jurij, Marc, Janja, Zavratnik, Andrej, Bogataj, Marija, Mrhar, Aleš
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Science Inc 2009
Ämnen:
Pharmacogenetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679107/
https://ncbi.nlm.nih.gov/pubmed/19371317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03363.x
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