Population pharmacokinetic modelling for enterohepatic circulation of mycophenolic acid in healthy Chinese and the influence of polymorphisms in UGT1A9

AIMS: To establish a population pharmacokinetic model that describes enterohepatic circulation (EHC) of mycophenolic acid (MPA) based on physiological considerations and to investigate the influence of polymorphisms of UGT1A9 on the pharmacokinetics of MPA. METHODS: Pharmacokinetic data were obtaine...

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Detalhes bibliográficos
Main Authors: Jiao, Zheng, Ding, Jun-jie, Shen, Jie, Liang, Hui-qi, Zhong, Long-jin, Wang, Yi, Zhong, Ming-kang, Lu, Wei-yue
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2485216/
https://ncbi.nlm.nih.gov/pubmed/18279479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03109.x
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