Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3

The pregnane X receptor is a ligand-activated transcription factor that is abundantly expressed in hepatocytes. Numerous drugs are pregnane X receptor ligands. To bind to their receptor they must cross the sinusoidal membrane. Organic anion transporting polypeptides 1B1 and 1B3 (OATP1B1 and OATP1B3)...

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Detalhes bibliográficos
Main Authors: Gui, Chunshan, Miao, Yi, Thompson, Lucas, Wahlgren, Bret, Mock, Melissa, Stieger, Bruno, Hagenbuch, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376123/
https://ncbi.nlm.nih.gov/pubmed/18321482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.01.042
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