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Inhibition of OATP-1B1 and OATP-1B3 by tyrosine kinase inhibitors

BACKGROUND: The potential of tyrosine kinase inhibitors (TKIs) interacting with other therapeutics through hepatic uptake transporter inhibition has not been fully delineated in drug-drug interactions (DDIs). This study was designed to estimate the half-maximal inhibitory concentration (IC(50)) valu...

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Bibliografske podrobnosti
izdano v:Drug Metabol Drug Interact
Main Authors: Khurana, Varun, Minocha, Mukul, Pal, Dhananjay, Mitra, Ashim K.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407688/
https://ncbi.nlm.nih.gov/pubmed/24807167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1515/dmdi-2014-0014
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