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Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro–in vivo correlations

BACKGROUND: Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS: The influence of 16 approved TKIs on transport was studied in vitro usi...

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Detalhes bibliográficos
Main Authors: Hu, S, Mathijssen, R H J, de Bruijn, P, Baker, S D, Sparreboom, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929889/
https://ncbi.nlm.nih.gov/pubmed/24398510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.811
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