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Inhibition of OATP1B1 by tyrosine kinase inhibitors: in vitro–in vivo correlations
BACKGROUND: Several tyrosine kinase inhibitors (TKIs) can decrease docetaxel clearance in patients by an unknown mechanism. We hypothesised that these interactions are mediated by the hepatic uptake transporter OATP1B1. METHODS: The influence of 16 approved TKIs on transport was studied in vitro usi...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3929889/ https://ncbi.nlm.nih.gov/pubmed/24398510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.811 |
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