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Interaction of three regio-specific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity
The human organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) are liver-enriched membrane transporters of major importance to hepatic uptake of numerous endogenous compounds including bile acids, steroid conjugates, hormones, and drugs including the 3-hydroxy-3-methylglut...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319192/ https://ncbi.nlm.nih.gov/pubmed/22352740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200629s |
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