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Contribution of hepatic organic anion transporting polypeptides (OATPs) to docetaxel uptake and clearance

The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of transporting radiolabeled docetaxel. By screening an array of...

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Publicat a:Mol Cancer Ther
Autors principals: Lee, Hannah H., Leake, Brenda F., Teft, Wendy, Tirona, Rommel G., Kim, Richard B., Ho, Richard H.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394048/
https://ncbi.nlm.nih.gov/pubmed/25695959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0547
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