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Contribution of hepatic organic anion transporting polypeptides (OATPs) to docetaxel uptake and clearance

The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of transporting radiolabeled docetaxel. By screening an array of...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Lee, Hannah H., Leake, Brenda F., Teft, Wendy, Tirona, Rommel G., Kim, Richard B., Ho, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394048/
https://ncbi.nlm.nih.gov/pubmed/25695959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0547
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