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Contribution of hepatic organic anion transporting polypeptides (OATPs) to docetaxel uptake and clearance

The antimicrotubular agent docetaxel is a widely used chemotherapeutic drug for the treatment of multiple solid tumors and is predominantly dependent on hepatic disposition. In this study, we evaluated drug uptake transporters capable of transporting radiolabeled docetaxel. By screening an array of...

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Bibliografski detalji
Izdano u:Mol Cancer Ther
Glavni autori: Lee, Hannah H., Leake, Brenda F., Teft, Wendy, Tirona, Rommel G., Kim, Richard B., Ho, Richard H.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394048/
https://ncbi.nlm.nih.gov/pubmed/25695959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0547
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