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Interaction of three regio-specific amino acid residues is required for OATP1B1 gain of OATP1B3 substrate specificity

The human organic anion-transporting polypeptides OATP1B1 (SLCO1B1) and OATP1B3 (SLCO1B3) are liver-enriched membrane transporters of major importance to hepatic uptake of numerous endogenous compounds including bile acids, steroid conjugates, hormones, and drugs including the 3-hydroxy-3-methylglut...

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Main Authors: DeGorter, Marianne K., Ho, Richard H., Leake, Brenda F., Tirona, Rommel G., Kim, Richard B.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319192/
https://ncbi.nlm.nih.gov/pubmed/22352740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200629s
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