Chemical-Genetic Screen Identifies Riluzole as an Enhancer of Wnt/β-catenin signaling in Melanoma

To identify new protein and pharmacological regulators of Wnt/β-catenin signaling we used a cell-based reporter assay to screen a collection of 1857 human-experienced compounds for their ability to enhance activation of the β-catenin reporter by a low concentration of WNT3A. This identified 44 uniqu...

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Hlavní autoři: Biechele, Travis L., Camp, Nathan D., Fass, Daniel M., Kulikauskas, Rima M., Robin, Nick C., White, Bryan D., Taraska, Corinne M., Moore, Erin C., Muster, Jeanot, Karmacharya, Rakesh, Haggarty, Stephen J., Chien, Andy J., Moon, Randall T.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044442/
https://ncbi.nlm.nih.gov/pubmed/21095567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.08.012
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