Chemical-Genetic Screen Identifies Riluzole as an Enhancer of Wnt/β-catenin signaling in Melanoma

To identify new protein and pharmacological regulators of Wnt/β-catenin signaling we used a cell-based reporter assay to screen a collection of 1857 human-experienced compounds for their ability to enhance activation of the β-catenin reporter by a low concentration of WNT3A. This identified 44 uniqu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Biechele, Travis L., Camp, Nathan D., Fass, Daniel M., Kulikauskas, Rima M., Robin, Nick C., White, Bryan D., Taraska, Corinne M., Moore, Erin C., Muster, Jeanot, Karmacharya, Rakesh, Haggarty, Stephen J., Chien, Andy J., Moon, Randall T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044442/
https://ncbi.nlm.nih.gov/pubmed/21095567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.08.012
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge