Chemical-Genetic Screen Identifies Riluzole as an Enhancer of Wnt/β-catenin signaling in Melanoma

To identify new protein and pharmacological regulators of Wnt/β-catenin signaling we used a cell-based reporter assay to screen a collection of 1857 human-experienced compounds for their ability to enhance activation of the β-catenin reporter by a low concentration of WNT3A. This identified 44 uniqu...

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Detalhes bibliográficos
Main Authors: Biechele, Travis L., Camp, Nathan D., Fass, Daniel M., Kulikauskas, Rima M., Robin, Nick C., White, Bryan D., Taraska, Corinne M., Moore, Erin C., Muster, Jeanot, Karmacharya, Rakesh, Haggarty, Stephen J., Chien, Andy J., Moon, Randall T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044442/
https://ncbi.nlm.nih.gov/pubmed/21095567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.08.012
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