ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

The human disorder ataxia telangiectasia (AT), which is characterized by genetic instability and neurodegeneration, results from mutation of the ataxia telangiectasia mutated (ATM) kinase. The loss of ATM leads to cell cycle checkpoint deficiencies and other DNA damage signaling defects that do not...

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Главные авторы: Rahal, Elias A, Henricksen, Leigh A, Li, Yuling, Williams, R Scott, Tainer, John A, Dixon, Kathleen
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040963/
https://ncbi.nlm.nih.gov/pubmed/20647759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.14.12363
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