Elimination Pathways of Systemically Delivered siRNA

The elimination process of systemically administered small interfering RNA (siRNA) was investigated by using siRNA labeled with an infrared fluorescent dye. A novel siRNA elimination pathway was identified. In this pathway, liver-enriched siRNA is secreted into the gallbladder and then emptied into...

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Bibliografiske detaljer
Main Authors: Huang, Yuanyu, Hong, Junmei, Zheng, Shuquan, Ding, Yi, Guo, Shutao, Zhang, Hongyan, Zhang, Xiuqin, Du, Quan, Liang, Zicai
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3034859/
https://ncbi.nlm.nih.gov/pubmed/21119623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.266
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