Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs

Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly in the treatment of single nucleotide polymorphism (SNP) diseases where discrimination against single nucleotide variation is demanded. However, no generally applicable guidelines are available for the d...

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Detalles Bibliográficos
Autores principales: Huang, Huang, Qiao, Renping, Zhao, Deyao, Zhang, Tong, Li, Youxian, Yi, Fan, Lai, Fangfang, Hong, Junmei, Ding, Xianfeng, Yang, Zhenjun, Zhang, Lihe, Du, Quan, Liang, Zicai
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2009
Materias:
Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794185/
https://ncbi.nlm.nih.gov/pubmed/19815667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp835
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