Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs

Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly in the treatment of single nucleotide polymorphism (SNP) diseases where discrimination against single nucleotide variation is demanded. However, no generally applicable guidelines are available for the d...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Huang, Huang, Qiao, Renping, Zhao, Deyao, Zhang, Tong, Li, Youxian, Yi, Fan, Lai, Fangfang, Hong, Junmei, Ding, Xianfeng, Yang, Zhenjun, Zhang, Lihe, Du, Quan, Liang, Zicai
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2009
Gaiak:
Molecular Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794185/
https://ncbi.nlm.nih.gov/pubmed/19815667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp835
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