Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs

Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly in the treatment of single nucleotide polymorphism (SNP) diseases where discrimination against single nucleotide variation is demanded. However, no generally applicable guidelines are available for the d...

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Main Authors: Huang, Huang, Qiao, Renping, Zhao, Deyao, Zhang, Tong, Li, Youxian, Yi, Fan, Lai, Fangfang, Hong, Junmei, Ding, Xianfeng, Yang, Zhenjun, Zhang, Lihe, Du, Quan, Liang, Zicai
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794185/
https://ncbi.nlm.nih.gov/pubmed/19815667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp835
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