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New insights into siRNA amplification and RNAi

In the nematode Caenorhabditis elegans (C. elegans), gene inactivation by RNA interference can achieve remarkable potency due to the amplification of initial silencing triggers by RNA-dependent RNA polymerases (RdRPs). RdRPs catalyze the biogenesis of an abundant species of secondary small interferi...

詳細記述

保存先:
書誌詳細
主要な著者: Zhang, Chi, Ruvkun, Gary
フォーマット: Artigo
言語:Inglês
出版事項: Landes Bioscience 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551858/
https://ncbi.nlm.nih.gov/pubmed/22858672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.21246
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