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siRNA Has Greatly Elevated Mismatch Tolerance at 3′-UTR Sites

It has been noted that target sites located in the coding region or the 3′-untranslated region (3′-UTR) can be silenced to significantly different levels by the same siRNA, but little is known about at what specificity the silencing was achieved. In an exploration of positional effects on siRNA spec...

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Detalhes bibliográficos
Main Authors: Wei, Na, Zhang, Lei, Huang, Huang, Chen, Yue, Zheng, Jie, Zhou, Xiao, Yi, Fan, Du, Quan, Liang, Zicai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493533/
https://ncbi.nlm.nih.gov/pubmed/23145149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049309
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