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siRNA Has Greatly Elevated Mismatch Tolerance at 3′-UTR Sites

It has been noted that target sites located in the coding region or the 3′-untranslated region (3′-UTR) can be silenced to significantly different levels by the same siRNA, but little is known about at what specificity the silencing was achieved. In an exploration of positional effects on siRNA spec...

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Dades bibliogràfiques
Autors principals: Wei, Na, Zhang, Lei, Huang, Huang, Chen, Yue, Zheng, Jie, Zhou, Xiao, Yi, Fan, Du, Quan, Liang, Zicai
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493533/
https://ncbi.nlm.nih.gov/pubmed/23145149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0049309
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