αENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus

Lithium-induced nephrogenic diabetes insipidus (NDI) is accompanied by polyuria, downregulation of aquaporin 2 (AQP2), and cellular remodeling of the collecting duct (CD). The amiloride-sensitive epithelial sodium channel (ENaC) is a likely candidate for lithium entry. Here, we subjected transgenic...

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Hlavní autoři: Christensen, Birgitte Mønster, Zuber, Annie Mercier, Loffing, Johannes, Stehle, Jean-Christophe, Deen, Peter M.T., Rossier, Bernard C., Hummler, Edith
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2011
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029898/
https://ncbi.nlm.nih.gov/pubmed/21051735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010070734
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