Sodium and Potassium Balance Depends on αENaC Expression in Connecting Tubule

Mutations in α, β, or γ subunits of the epithelial sodium channel (ENaC) can downregulate ENaC activity and cause a severe salt-losing syndrome with hyperkalemia and metabolic acidosis, designated pseudohypoaldosteronism type 1 in humans. In contrast, mice with selective inactivation of αENaC in the...

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Bibliografiske detaljer
Main Authors: Christensen, Birgitte Mønster, Perrier, Romain, Wang, Qing, Zuber, Annie Mercier, Maillard, Marc, Mordasini, David, Malsure, Sumedha, Ronzaud, Caroline, Stehle, Jean-Christophe, Rossier, Bernard C., Hummler, Edith
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2010
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014008/
https://ncbi.nlm.nih.gov/pubmed/20947633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009101077
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