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Structural Basis for Activation of Class Ib Ribonucleotide Reductase
The class Ib ribonucleotide reductase of Escherichia coli can initiate reduction of nucleotides to deoxynucleotides with either a Mn(III)(2)-tyrosyl radical (Y•) or a Fe(III)(2)-Y• cofactor in the NrdF subunit. Whereas Fe(III)(2)-Y• can self-assemble from Fe(II)(2)-NrdF and O(2), activation of Mn(II...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3020666/ https://ncbi.nlm.nih.gov/pubmed/20688982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190187 |
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