Streptococcus sanguinis Class Ib Ribonucleotide Reductase: HIGH ACTIVITY WITH BOTH IRON AND MANGANESE COFACTORS AND STRUCTURAL INSIGHTS

Streptococcus sanguinis is a causative agent of infective endocarditis. Deletion of SsaB, a manganese transporter, drastically reduces S. sanguinis virulence. Many pathogenic organisms require class Ib ribonucleotide reductase (RNR) to catalyze the conversion of nucleotides to deoxynucleotides under...

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Autores principales: Makhlynets, Olga, Boal, Amie K., Rhodes, DeLacy V., Kitten, Todd, Rosenzweig, Amy C., Stubbe, JoAnne
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937692/
https://ncbi.nlm.nih.gov/pubmed/24381172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533554
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