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Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese?
Ribonucleotide reductases (RNRs) convert nucleotides to deoxynucleotides in all organisms. Activity of the class Ia and Ib RNRs requires a stable tyrosyl radical (Y•), which can be generated by reaction of O(2) with a diferrous cluster on the β subunit to form active diferric-Y• cofactor. Recent exp...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3074109/ https://ncbi.nlm.nih.gov/pubmed/21216656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2010.12.001 |
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