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Control of metallation and active cofactor assembly in the class Ia and Ib ribonucleotide reductases: diiron or dimanganese?

Ribonucleotide reductases (RNRs) convert nucleotides to deoxynucleotides in all organisms. Activity of the class Ia and Ib RNRs requires a stable tyrosyl radical (Y•), which can be generated by reaction of O(2) with a diferrous cluster on the β subunit to form active diferric-Y• cofactor. Recent exp...

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Bibliografske podrobnosti
Main Authors: Stubbe, JoAnne, Cotruvo, Joseph A.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074109/
https://ncbi.nlm.nih.gov/pubmed/21216656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2010.12.001
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