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Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo

Escherichia coli class Ib ribonucleotide reductase (RNR) converts nucleoside 5′-diphosphates to deoxynucleoside 5′-diphosphates in iron-limited and oxidative stress conditions. We have recently demonstrated in vitro that this RNR is active with both diferric-tyrosyl radical (Fe(III)(2)-Y•) and diman...

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Bibliografiske detaljer
Main Authors: Cotruvo, Joseph A., Stubbe, JoAnne
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076206/
https://ncbi.nlm.nih.gov/pubmed/21250660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101881d
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