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Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: Enzymatic generation of superoxide is required for tyrosine oxidation via a Mn(III)Mn(IV) intermediate

Ribonucleotide reductases (RNRs) utilize radical chemistry to reduce nucleotides to deoxynucleotides in all organisms. In the class Ia and Ib RNRs, this reaction requires a stable tyrosyl radical (Y•) generated by oxidation of a reduced dinuclear metal cluster. The Fe(III)(2)-Y• cofactor in the NrdB...

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書誌詳細
主要な著者: Cotruvo, Joseph A., Stich, Troy A., Britt, R. David, Stubbe, JoAnne
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739481/
https://ncbi.nlm.nih.gov/pubmed/23402532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja312457t
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