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Structural Basis for Activation of Class Ib Ribonucleotide Reductase

The class Ib ribonucleotide reductase of Escherichia coli can initiate reduction of nucleotides to deoxynucleotides with either a Mn(III)(2)-tyrosyl radical (Y•) or a Fe(III)(2)-Y• cofactor in the NrdF subunit. Whereas Fe(III)(2)-Y• can self-assemble from Fe(II)(2)-NrdF and O(2), activation of Mn(II...

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Bibliografische gegevens
Hoofdauteurs: Boal, Amie K., Cotruvo, Joseph A., Stubbe, JoAnne, Rosenzweig, Amy C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020666/
https://ncbi.nlm.nih.gov/pubmed/20688982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190187
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