The Presence of a vpu Gene and the Lack of Nef-Mediated Downmodulation of T Cell Receptor-CD3 Are Not Always Linked in Primate Lentiviruses

Nef is an accessory protein critical for the ability of human and simian immunodeficiency viruses (HIV and SIV) to replicate efficiently in their respective hosts. Previous analyses of members of 15 different primate lentivirus lineages revealed a link between Nef function and the presence of a vpu...

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Bibliographische Detailangaben
Hauptverfasser: Schmökel, Jan, Sauter, Daniel, Schindler, Michael, Leendertz, Fabian H., Bailes, Elizabeth, Dazza, Marie-Christine, Saragosti, Sentob, Bibollet-Ruche, Frederic, Peeters, Martine, Hahn, Beatrice H., Kirchhoff, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2011
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020008/
https://ncbi.nlm.nih.gov/pubmed/21068258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02087-10
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