The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild

The cellular factor serine incorporator 5 (SERINC5) impairs HIV-1 infectivity but is antagonized by the viral Nef protein. We analyzed the anti-SERINC5 activity of Nef proteins across primate lentiviruses and examined whether SERINC5 represents a barrier to cross-species transmissions and/or within-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Host Microbe
Prif Awduron: Heigele, Anke, Kmiec, Dorota, Regensburger, Kerstin, Langer, Simon, Peiffer, Lukas, Stürzel, Christina M., Sauter, Daniel, Peeters, Martine, Pizzato, Massimo, Learn, Gerald H., Hahn, Beatrice H., Kirchhoff, Frank
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098270/
https://ncbi.nlm.nih.gov/pubmed/27631701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2016.08.004
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