HIV-1 Nef Antagonizes SERINC5 Restriction by Downregulation of SERINC5 via the Endosome/Lysosome System

The primate lentiviral accessory protein Nef downregulates CD4 and major histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal trafficking pathways to promote viral pathogenesis. In addition, Nef antagonizes a novel restriction factor, SERINC5 (Ser5), to increase...

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Publicado en:J Virol
Autores principales: Shi, Jing, Xiong, Ran, Zhou, Tao, Su, Peiyi, Zhang, Xihe, Qiu, Xusheng, Li, Hongmei, Li, Sunan, Yu, Changqing, Wang, Bin, Ding, Chan, Smithgall, Thomas E., Zheng, Yong-Hui
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Virus-Cell Interactions
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5952139/
https://ncbi.nlm.nih.gov/pubmed/29514909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00196-18
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