Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

The interferon-induced host restriction factor tetherin poses a barrier for SIV transmission from primates to humans. Following cross-species transmission, the chimpanzee precursor of pandemic HIV-1 switched from the accessory protein Nef to Vpu to effectively counteract human tetherin. As we report...

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Hauptverfasser: Götz, Nicola, Sauter, Daniel, Usmani, Shariq M., Fritz, Joëlle V., Goffinet, Christine, Heigele, Anke, Geyer, Matthias, Bibollet-Ruche, Frederic, Learn, Gerald H., Fackler, Oliver T., Hahn, Beatrice H., Kirchhoff, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444822/
https://ncbi.nlm.nih.gov/pubmed/22980333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.07.008
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