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Allosteric Interactions between the Myristate- and ATP-Site of the Abl Kinase
Abl kinase inhibitors targeting the ATP binding pocket are currently employed as potent anti-leukemogenic agents but drug resistance has become a significant clinical limitation. Recently, a compound that binds to the myristate pocket of Abl (GNF-5) was shown to act cooperatively with nilotinib, an...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018526/ https://ncbi.nlm.nih.gov/pubmed/21264348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015929 |
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