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Creating Designed Zinc Finger Nucleases with Minimal Cytotoxicity

Zinc finger nucleases (ZFNs) have emerged as powerful tools for delivering a targeted genomic double-strand break (DSB) to either stimulate local homologous recombination (HR) with investigator-provided donor DNA or induce gene mutations at the site of cleavage in absence of a donor by non-homologou...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ramalingam, Sivaprakash, Kandavelou, Karthikeyan, Rajenderan, Raja, Chandrasegaran, Srinivasan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017627/
https://ncbi.nlm.nih.gov/pubmed/21094162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.043
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