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Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage
Custom-designed zinc finger nucleases (ZFNs) are becoming powerful tools in gene targeting—the process of replacing a gene within a genome by homologous recombination. Here, we have studied the DNA cleavage by one such ZFN, ΔQNK-FN, in order to gain insight into how ZFNs cleave DNA and how two inver...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4170802/ https://ncbi.nlm.nih.gov/pubmed/16043120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2005.07.021 |
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