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Creating Designed Zinc Finger Nucleases with Minimal Cytotoxicity
Zinc finger nucleases (ZFNs) have emerged as powerful tools for delivering a targeted genomic double-strand break (DSB) to either stimulate local homologous recombination (HR) with investigator-provided donor DNA or induce gene mutations at the site of cleavage in absence of a donor by non-homologou...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017627/ https://ncbi.nlm.nih.gov/pubmed/21094162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.043 |
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