Targeted Manipulation of Mammalian Genomes using Designed Zinc Finger Nucleases

Targeted introduction of a double-stranded break (DSB) using designer zinc finger nucleases (ZFNs) in mammalian cells greatly enhances gene targeting - homologous recombination (HR) at a chosen endogenous target gene, which otherwise is limited by low spontaneous rate of HR. Here, we report that eff...

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Huvudupphovsmän: Kandavelou, Karthikeyan, Ramalingam, Sivaprakash, London, Viktoriya, Mani, Mala, Wu, Joy, Alexeev, Vitali, Civin, Curt I., Chandrasegaran, Srinivasan
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744961/
https://ncbi.nlm.nih.gov/pubmed/19635463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.07.112
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