Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells

Custom-designed zinc finger nucleases (ZFNs), proteins designed to cut at specific DNA sequences, are becoming powerful tools in gene targeting—the process of replacing a gene within a genome by homologous recombination (HR). ZFNs that combine the non-specific cleavage domain (N) of FokI endonucleas...

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Detalhes bibliográficos
Main Authors: Durai, Sundar, Mani, Mala, Kandavelou, Karthikeyan, Wu, Joy, Porteus, Matthew H., Chandrasegaran, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1270952/
https://ncbi.nlm.nih.gov/pubmed/16251401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki912
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