Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

Although activating mutations in RAS oncogenes are known to result in aberrant signaling through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program remains poorly characterized. Here we demonstrate that Ras activation leads to repression of the miR-143/145 cluster in cell...

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Détails bibliographiques
Auteurs principaux: Kent, Oliver A., Chivukula, Raghu R., Mullendore, Michael, Wentzel, Erik A., Feldmann, Georg, Lee, Kwang H., Liu, Shu, Leach, Steven D., Maitra, Anirban, Mendell, Joshua T.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2010
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003192/
https://ncbi.nlm.nih.gov/pubmed/21159816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1950610
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