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Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway
Although activating mutations in RAS oncogenes are known to result in aberrant signaling through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program remains poorly characterized. Here we demonstrate that Ras activation leads to repression of the miR-143/145 cluster in cell...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Cold Spring Harbor Laboratory Press
2010
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003192/ https://ncbi.nlm.nih.gov/pubmed/21159816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1950610 |
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