Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

Although activating mutations in RAS oncogenes are known to result in aberrant signaling through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program remains poorly characterized. Here we demonstrate that Ras activation leads to repression of the miR-143/145 cluster in cell...

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書誌詳細
主要な著者: Kent, Oliver A., Chivukula, Raghu R., Mullendore, Michael, Wentzel, Erik A., Feldmann, Georg, Lee, Kwang H., Liu, Shu, Leach, Steven D., Maitra, Anirban, Mendell, Joshua T.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2010
主題:
Research Communication
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003192/
https://ncbi.nlm.nih.gov/pubmed/21159816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1950610
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