Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

Although activating mutations in RAS oncogenes are known to result in aberrant signaling through multiple pathways, the role of microRNAs (miRNAs) in the Ras oncogenic program remains poorly characterized. Here we demonstrate that Ras activation leads to repression of the miR-143/145 cluster in cell...

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Detalhes bibliográficos
Main Authors: Kent, Oliver A., Chivukula, Raghu R., Mullendore, Michael, Wentzel, Erik A., Feldmann, Georg, Lee, Kwang H., Liu, Shu, Leach, Steven D., Maitra, Anirban, Mendell, Joshua T.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2010
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003192/
https://ncbi.nlm.nih.gov/pubmed/21159816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1950610
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