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Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4
CD4 binds to MHC class II molecules and enhances T-cell activation. The CD4-related transmembrane protein LAG-3 (lymphocyte activation gene-3, CD223) binds to the same ligand but inhibits T-cell proliferation. We have previously shown that LAG-3 cell surface expression is tightly regulated by extrac...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2987677/ https://ncbi.nlm.nih.gov/pubmed/20391435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939874 |
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