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Lymphocyte-Activation Gene 3 (LAG3): the Next Immune Checkpoint Receptor

Immune checkpoint therapy has revolutionized cancer treatment by blocking inhibitory pathways in T cells that limits the an effective anti-tumor immune response. Therapeutics targeting CTLA-4 and PD1/PDL1 have progressed to first line therapy in multiple tumor types with some patients exhibiting tum...

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Detalhes bibliográficos
Publicado no:Semin Immunol
Main Authors: Ruffo, Elisa, Wu, Richard, Bruno, Tullia C., Workman, Creg J., Vignali, Dario A.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6920665/
https://ncbi.nlm.nih.gov/pubmed/31604537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2019.101305
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