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Metalloproteases regulate T-cell proliferation and effector function via LAG-3
Tight control of T-cell proliferation and effector function is essential to ensure an effective but appropriate immune response. Here, we reveal that this is controlled by the metalloprotease-mediated cleavage of LAG-3, a negative regulatory protein expressed by all activated T cells. We show that L...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783452/ https://ncbi.nlm.nih.gov/pubmed/17245433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601520 |
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