Metalloproteases regulate T-cell proliferation and effector function via LAG-3

Tight control of T-cell proliferation and effector function is essential to ensure an effective but appropriate immune response. Here, we reveal that this is controlled by the metalloprotease-mediated cleavage of LAG-3, a negative regulatory protein expressed by all activated T cells. We show that L...

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Main Authors: Li, Nianyu, Wang, Yao, Forbes, Karen, Vignali, Kate M, Heale, Bret S, Saftig, Paul, Hartmann, Dieter, Black, Roy A, Rossi, John J, Blobel, Carl P, Dempsey, Peter J, Workman, Creg J, Vignali, Dario A A
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783452/
https://ncbi.nlm.nih.gov/pubmed/17245433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601520
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