Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4

CD4 binds to MHC class II molecules and enhances T-cell activation. The CD4-related transmembrane protein LAG-3 (lymphocyte activation gene-3, CD223) binds to the same ligand but inhibits T-cell proliferation. We have previously shown that LAG-3 cell surface expression is tightly regulated by extrac...

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Hlavní autoři: Woo, Seng-Ryong, Li, Nianyu, Bruno, Tullia C., Forbes, Karen, Brown, Scott, Workman, Creg, Drake, Charles G., Vignali, Dario A. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987677/
https://ncbi.nlm.nih.gov/pubmed/20391435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939874
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