Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

Small molecules stabilize specific protein conformations from a larger ensemble, enabling molecular switches that control diverse cellular functions. We show here that the converse also holds true, where the conformational state of the estrogen receptor can direct distinct orientations of the bound...

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Detaylı Bibliyografya
Asıl Yazarlar: Bruning, John B., Parent, Alex A., Gil, German, Zhao, Min, Nowak, Jason, Pace, Margaret C., Smith, Carolyn L., Afonine, Pavel V., Adams, Paul D., Katzenellenbogen, John A., Nettles, Kendall W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974172/
https://ncbi.nlm.nih.gov/pubmed/20924370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.451
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