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Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity
Small molecules stabilize specific protein conformations from a larger ensemble, enabling molecular switches that control diverse cellular functions. We show here that the converse also holds true, where the conformational state of the estrogen receptor can direct distinct orientations of the bound...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2974172/ https://ncbi.nlm.nih.gov/pubmed/20924370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.451 |
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