Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1–infected individuals, but the virologic basis of their neutralization remains poorly understood. We used knowledge of HIV-1 envelope structure to develop antigenically resurfaced glycoproteins specific for the structur...

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Bibliografski detalji
Glavni autori: Wu, Xueling, Yang, Zhi-Yong, Li, Yuxing, Hogerkorp, Carl-Magnus, Schief, William R., Seaman, Michael S., Zhou, Tongqing, Schmidt, Stephen D., Wu, Lan, Xu, Ling, Longo, Nancy S., McKee, Krisha, O'Dell, Sijy, Louder, Mark K., Wycuff, Diane L., Feng, Yu, Nason, Martha, Doria-Rose, Nicole, Connors, Mark, Kwong, Peter D., Roederer, Mario, Wyatt, Richard T., Nabel, Gary J., Mascola, John R.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2965066/
https://ncbi.nlm.nih.gov/pubmed/20616233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1187659
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